The holy gaon, Reb Yeshaya Halevi Horowitz was born in approximately the year 5230 (1470). His father R' Avrohom Halevi was dayan in Prague, Cracow and lastly in Lemberg. R' Yeshaya learnt with his father and with the gaon R' Shlomo Ben Reb Yehudah Leib zt"l, better known as the Maharshal Hasheini, the second Maharshal. He also learnt with the Maharam of Lublin, zt"l.
He married Chaya, daughter of one of the prominent members of the community in Vienna, Rabbi Avrohom Moyal. In an awesome statement, R' Sheftel zt"l later wrote about his mother, the Rebbetzin Chaya, "It was said in her generation that she lacked nothing in deeds and traits of the holy Imahos, Soroh, Rivka, Rochel and Leah."
Over the years, R' Yeshaya Halevi practiced as rov in various communities: in 5260 (1500) in Dubno, Russia, in 5262 in Ostroa and from 5266 he took over the reins in Frankfurt, leading the prestigious kehilla until their expulsion from the city on 27 Elul 5274 (1514). The rabbi was exiled together with his flock and he returned to Prague, where he was appointed Rov in 5275 (1515).
When his Rebbetzin passed away on 4th Adar 5280 (1520), Reb Yeshaya Halevi decided to make his dream of going to live in Eretz Yisroel a reality. On 8th Elul 5281 the Shloh boarded the ship and after a turbulent, difficult journey he arrived in the holy land on 2nd Kislev, 5282. Upon reaching Yerushalayim, he was immediately accepted as Chief Rabbi of Eretz Yisroel.
Seeing the immense poverty of the settlers in the holy land, the Shloh sent messengers to the Diaspora and their Rabbonim, particularly to the communities where he had served as rov, initiating a tzedokoh campaign which he called "Yachatz" -- an acronym in Hebrew for the three cities Yerushalayim, Chevron and Tzfas.
On 11th Elul, 5285 (1525), the Shloh was imprisoned due to a libel trumped up by the wicked Machmed Ibn Paroueh. On Rosh Hashonoh, start of the year 5286 he was freed and he fled to Tzfas and Teveriah. There he established his center of learning and prayer in the ancient Beis Haknesses on the shores of the Kinneret in Teveriah.
He was niftar on 11th Nissan and is buried in the old cemetery in Teveriah close to the tzion of Rabbi Yochanan Ben Zakai.
His holy seforim were accepted and beloved by Jews the world over, a fact which is proven by the amount of times his great sefer Shnei Luchos Habris had to be printed over and over.
http://www.chareidi.org/archives5761/vayikra/features2.htm
His famous siddur Shaar Hashomayim is also well known (In Skver they have a minhag to daven from it) and in reference to it the Sulitza Rebbe ztzl of Far Rockaway who himself davened from the Siddur HaShelah showed me and told me that Rav Yoel Sirkis author of the Bach on the Tur wrote in his approbation, "I guarantee that whoever davens with this siddur, his tefillos will be accepted."
